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1 Clinical Use of GLP-1 and GLP-1/GIP RAs Approved Agents and Dosing GLP-1 RAs have a relatively long half-life of approximately one week

Unlike standard IGF1, the LR3 version has two key modifications that enhance its potency and duration: The Long designation refers to an additional 13 amino acids, increasing its molecular stability The Arg3 substitution reduces its binding to IGF-binding proteins (IGFBPs), extending half-life from minutes to ~2030 hours These changes allow IGF1 LR3 to remain active in the bloodstream much longer than endogenous IGF1, resulting in greater anabolic signaling and sustained muscle growth potential

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Exenatide IR (immediate-release) is given twice daily, while exenatide ER is a once-weekly microsphere formulation