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These drugs mimic the action of naturally occurring GLP-1, an incretin hormone released by the intestine in response to food intake
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(As a reminder, every medication is different, so patients should refer to the packaging for a full list of indications.) GLP-1s can help slow down how the stomach empties, which may help reduce a persons appetite
As a GLP-1 receptor agonist, Ozempic works by regulating appetite, slowing gastric emptying, and promoting satiety, which can help reduce overall calorie intake
For example, INT-777 and MN6, TGR5 selective agonists, stimulated GLP-1 secretion and improved insulin sensitivity in diet-induced obesity (DIO) mice [180, 181]
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