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In addition, circulating GLP-1 enters circumventricular areas of the CNSsuch as the subfornical organ, the organum vasculosum of the lamina terminalis, the median eminence near the arcuate nucleus, and the area postremathanks to the partial permeability of the bloodbrain barrier.2,3,6 In addition, NTS neurons, which receive peripheral afferent input, synthesise preproglucagon and serve as a source of GLP-1 within the CNS
Three participants withdrew or were lost to follow up and two participants experienced protocol deviations
In December 2024, NICE recommended the use of tirzepatide (Mounjaro), alongside semaglutide (Wegovy) and liraglutide (Saxenda), for the treatment of weight-related comorbidities.10 NICE recommended these drugs alongside diet and exercise, yet many patients lack structured programs offering nutritional, behavioural, and psychological support
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Accessed May 9, 2024 .] Approved for weight loss in November 2023 under the name Zepbound, tirzepatide was approved as the diabetes drug Mounjaro in 2022
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