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The subsequent increase in ATP/ADP ratio leads to a closure of ATP-sensitive K + channels, intracellular accumulation of K + ions and subsequent membrane depolarization, causing an influx of Ca 2+ via voltage dependent Ca 2+ channels (VDCC)

Duration: Episodes last a median of 2 days

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It is used as adjuvant therapy to treat and prevent various medical conditions that arise from nutritional deficiencies or long term disorders

The combination of blood stasis due to LV wall motion abnormalities, endothelial ischemic injury, and hypercoagulability associated with the acute pro-inflammatory state, creates a highly thrombogenic myocardial environment favouring thrombus formation (227)