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There can be concomitant lactic acidosis, acute kidney injury, hypoglycemia, and rapid neurologic decline within the first 72h, with marked cerebral edema

Not a diagnosis

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The most common side effect is developing flu-like symptoms after receiving the injection

We note that although the chondroprotective effects of metformin was clearly attenuated in Nrf2 KO mice, micro-CT analysis revealed some variability in trabecular bone parameters, including occasional increases in subchondral trabecular bone amounts in Nrf2 KO OA mice (Fig

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