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Freezing can cause irreversible damage to the protein structure, rendering the medication ineffective or potentially unsafe
When faced with such a prospect, a 24-h clear liquid diet does not seem to pose an equal risk or inconvenience. The bottom line is this: the most risk-mitigating approach based on the evidence would be to have patients fast for longer (ideally no solids for 24 hours and no liquids for perhaps longer than 2 hours)
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It can also lead to increased pain and bruising
PMID 14886311
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