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Compared to thermogenics and stimulants Traditional thermogenic compounds like caffeine, synephrine, or more potent stimulants increase metabolic rate through sympathetic nervous system activation

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Additionally, hypobaric hypoxia can stimulate immune cells, such as macrophages and lymphocytes, to release a variety of inflammatory mediators, including tumor necrosis factor-alpha (TNF-), IL-1, IL-6 and nitric oxide (NO), as shown in Figure 1

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The multi-pathway mechanism appears to address fundamental aspects of wound healing common across these diverse injuries

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