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It should be noted that while the HIF pathway can induce antioxidant genes like SOD2 to maintain adaptive balance under acute hypoxia, this protective effect in chronic diseases like cancer may conversely aid malignant cells in resisting apoptosis, constituting another dimension of intervention complexity [501]

The Lancet Healthy Longevity, 3 (1), e67-e77

As we age, the regulation of gene expression becomes less precise

doi: 10.3390/biom10010084 2

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