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Supplementary material The Supplementary Material for this article can be found online at: References 1 TalbotKWangH-Y

The microbiome has significantly enriched metabolism of glycans, amino acids, xenobiotics, methanogenesis and 2-methyl-d-erythritol 4-phosphate pathway-mediated biosynthesis of vitamins and isoprenoids (88, 93)

It is important to note that many of the studies examining the efficacy of lipoic acid for the treatment of diabetic neuropathy have been conducted by one German research group and funded by the manufacturer of lipoic acid in Germany

(This prevents creating a vacuum and makes insulin withdrawal easier.)

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