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Yeast mitochondrial NAD(+)-dependent isocitrate dehydrogenase is an RNA-binding protein [PMID: 7505425] Laboratory literature summary: Yeast mitochondrial NAD(+)-dependent isocitrate dehydrogenase is an RNA-binding protein
The pharmacology in animal studies and early human studies supported this design: AOD-9604 stimulates lipolysis and inhibits lipogenesis through activation of beta-3 adrenergic receptors in adipose tissue, without producing the IGF-1 elevation or insulin resistance signal that exogenous GH produces
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This rapid clearance contributes to the favorable safety profile, as the compound itself does not accumulate in tissues
On the other hand, patients with inactive GHRH receptor, due to mutations, still had rhythmic GH secretion, suggesting that another factor, different to GHRH, was inducing pituitary GH secretion [177]
