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Recent Developments In September 2025, Eli Lilly released data showing orforglipron lowered A1C by 2.2 % vs 1.4 % for oral semaglutide at highest doses

It is important to note that the upregulation of IL-33 observed in some GLP-1 studies does not universally guarantee mucosal defense, as IL-33 can also drive potent Th2 inflammatory responses depending on the tissue context ( In 2024, Sun and colleagues investigated GLP-1 receptor agonists in a DSS-colitis model

150 mg Lactoplantibacillus plantarum 815 (LP815) (1B CFU)

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