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Some studies have reported that knockdown of GLP-1R in ARC POMC neurons didnt alter body weight or composition, food intake, and energy expenditure, nor did it significantly alter the reduction of food intake by intraperitoneal (i.p.) exendin-4 [80]
doi: 10.1016/j.chemosphere.2006.05.132 128 GillRLanniLJenKLMcCabeMJJrRosenspireA
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