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All these trials were designed to evaluate the primary outcome of 3-MACE defined as cardiovascular death, nonfatal myocardial infarct, and nonfatal stroke, except for the ELIXA trial of exenatide ER, which included hospitalization for unstable angina as an additional component of the 4-MACE composite outcomes

Pulldown and coimmunoprecipitation assays revealed that the interaction between S100A2 and Hsp70/Hsp90-organizing protein or kinesin-light chain through tetratricopeptide domain modulates protein complex folding and KLC-cargo interaction (61)

Ozempic: Subcutaneous injection approved by the FDA on December 5, 2017, to lower blood sugar in people with type 2 diabetes and off-label for weight loss in people with obesity and overweight

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