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Titration Phase : After 4 weeks, the dose is increased to 0.5 mg weekly

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sALS and fALS share several features, including protein aggregation, motor neuron hyperexcitability, trafficking defects, disruption of nucleocytoplasmic transport, oxidative stress, mitochondrial dysfunction, glutamate excitotoxicity, and neuroinflammation

Regular healthcare provider consultation ensures proper administration protocols and side effect management

While a higher dose might seem like a shortcut, our observations from research data suggest it often just increases the intensity of side effects like nausea and flushing without significantly accelerating the pigmentation process

Mutagenesis and MD simulations confirmed the crucial interactions and structural adjustments involved in this modulation