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As the rate-limiting enzyme in the oxidation of LCFAs, CPT1 has three isoenzymes, CPT1A, CPT1B and CPT1C, which exhibit significantly different kinetic and regulatory properties

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M is the 12 C ion of the metabolite

Since we did not detect a decrease in pyruvate in the cortex (Supplementary Table 7), these results could suggest there may be reduced lactate dehydrogenase activity in astrocytes, as lactate can be produced downstream from glucose to support energy needs in neurons

Many of the signatories have left messages crediting peptides with improving their health