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DSIP has been administered to both human and animal populations in randomized and controlled studies [18, 19]

This makes oral delivery the preferred route for GI-specific indications, while injectable delivery is preferred for systemic tissue repair goals (joint, muscle, tendon, systemic inflammation)

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The resulting elevated concentrations of homocysteine and MMA are often found in patients with low serum vitamin B 12 and can usually be lowered with successful vitamin B 12 replacement therapy

Most of the B12 from sublingual products is likely swallowed and absorbed through the same intestinal mechanisms as regular tablets

DOI: 10.1007/BF02978833