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Without that distinction, delayed patterns can be mistaken for negative or unclear results

FOXO4-DRI vs nearby senolytics Option FOXO4-DRI Type D-retro-inverso peptide Human trial stage None (preclinical only) Option Dasatinib + Quercetin (D+Q) Type Small-molecule drug + flavonoid Human trial stage Early human trials (e.g., Alzheimer's) Option Navitoclax Type BCL-2 family inhibitor Human trial stage Later-stage trials (e.g., myelofibrosis) D+Q and navitoclax are further along in humans but can affect healthy cells (e.g., low platelets)

JAMA 314:687699 Marso SP, Daniels GH, Brown-Frandsen K et al (2016) Liraglutide and cardiovascular outcomes in type 2 diabetes

What does Aetna typically want to see in a PA request for a weight loss drug

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Weight loss results In a 2022 review of 22 studies that included more than 17,000 people with or without type 2 diabetes treated with semaglutide or liraglutide: More than 50% of participants treated with either semaglutide or liraglutide lost 5% or more of their starting weight after an average of 39 weeks on the medicine About 17% of participants lost 10% or more of their body weight in the same period A phase 3 clinical trial studied treatment with tirzepatide in people with obesity and found that it produced substantial and sustained weight loss at various dose strengths