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Bottom line: these drugs overpromise and can make medium-term weight gain worse if you stop (which half of people do within a year in real-world data)

Orforglipron will likely be available within 12-18 months with no food or water restrictions

Candy, pastries, sugary cereals, and sweetened beverages can cause blood sugar fluctuations and may intensify cravings

Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach

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MC4R activation suppresses appetite (the mechanism behind setmelanotide, an FDA-approved MC4R agonist for obesity), but also triggers nausea, facial flushing, and spontaneous erections in males at doses above 0.5mg in nave users