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Fibroblasts obtained from ALS patients carrying the CHCHD10 mutation S59L display respiratory chain deficiency, ultrastructural alterations, and fragmentation of the mitochondrial network (Bannwarth et al., 2020)
Patients should use medications only as prescribed and discuss potential benefits, risks, and treatment alternatives with their healthcare provider
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Fatigue may result from multiple factors including significant caloric deficit from appetite suppression, metabolic adaptation to weight loss, nutritional deficiencies, gastrointestinal side effects affecting food and fluid intake, and changes in blood glucose levels
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