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Mitochondrial dysfunction leading to oxidative stress also induces FGF21 expression in preclinical disease models (110), while levels of FGF21 are elevated in the circulation and skeletal muscle of patients with myopathies caused by mutations in components of the mitochondrial oxidative phosphorylation machinery (111)

For rd1 , the calibration set consists of the [GSH] and [GSSG] measurements at PN11, PN12 and PN13, and the validation set contains the data at PN15, PN17 and PN28