Previously, we have been mostly prescribing it for our patients who either need significant weight loss before surgery or those who are post-surgery and struggling, either not having lost enough or gaining back weight
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We compared a 6 and 12-month change in total body weight loss (TBWL) for those receiving monotherapy from the initiation of GLP-1 analogue therapy with those receiving combination therapy from the initiation of bupropion/naltrexone added-on therapy
Figure 3: Head-to-head efficacy comparison restricted to Standard-design, Non-T2D trials
That reduction in eating can also mean a reduction in protein, which the body needs to maintain and repair muscle tissue