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10.1016/j.jad.2019.11.061 35

These findings demonstrate that X(PC) can cleave full-length procaspase-1 in protein lysates even though it was evolved on only a 17-amino-acid substrate fragment, procaspase-1 (residues 304320)

Cell 163 (7), 15851595

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Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)

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