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The isoelectric point is 4.65.1 , making it acidic and negatively charged at physiological pH
Randomised, double-blind, placebo-controlled parallel group study of P54FP for the treatment of dogs with osteoarthritis
- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)
In trials both components are titrated weekly in parallel toward 2.4 mg + 2.4 mg once weekly over roughly 16 weeks
At present, there are no randomized controlled trials in humans
High Caco-2 permeability is a favorable sign for oral absorption
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