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Chronic protocols require lower sustained doses to avoid receptor desensitisation

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Insulin works by binding to insulin receptors on the surface of cells

Diamanti-Kandarakis, E., Papavassiliou, A

Furthermore, in pacing-induced heart failure model, the stimulation of GLP signaling with GLP-1 has also been demonstrated to improve cardiac performance in conscious dogs with dilated cardiomyopathy [25]