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Owen, M
Although direct neo-N-terminal fragments of caspase-1 were not enriched in the TMT-TAILS dataset, potentially due to labeling inefficiencies, we observed significant depletion of peptides spanning the X(PC) cleavage site in the active protease-treated samples, providing strong evidence of on-target cleavage (Extended Data Fig
As such, the CJC-1295 and Ipamorelin blend continues to serve as a valuable experimental construct for advancing mechanistic understanding of peptide-driven endocrine regulation rather than for clinical or therapeutic interpretation
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Expected Efficacy
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