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Gastrointestinal Effects The most frequent adverse effects of GLP-1RAs are gastrointestinal, including nausea, vomiting, diarrhoea and a sensation of early satiety

The dominant battleground is shifting from injectable GLP-1 mono toward oral small molecules and multi-agonist combinations

Constant mild nausea with peaks after eating

Basi and his team

Patients who understand their genetic predispositions often achieve better compliance and more personalized dosing strategies

The weight-loss results continued to the 48-week endpoint, with the 12 mg retatrutide group achieving a mean weight reduction of -24.2%, while the placebo group only saw a -2.1% change