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[57] Central nervous system and appetite regulation [edit] Semaglutide crosses the blood-brain barrier to interact with the arcuate nucleus of the hypothalamus, a crucial brain region for energy balance

However, the concept of enterotypes has been debated due to the high degree of variability observed in the gut microbiota between individuals and the fact that many of the data show that there are not three completely discrete clusters (Knights et al., 2014)