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At night, rising melatonin acts on MT1/MT2 receptors in various tissues to induce nighttime physiology: it promotes the onset of sleep, lowers core body temperature, slows gastrointestinal activity, and modulates metabolism to a nocturnal state
Factors such as individual metabolism, nutrient levels, and overall health can influence how quickly the effects are felt
Although most proteins required for mitochondrial function are encoded by nuclear DNA and synthesised by cytoplasmic ribosomes for targeted transport [30], regular respiratory chain activity requires structurally intact and functionally normal mitochondrial genes [31]
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