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In macrophage models, -KG promotes JMJD3-mediated H3K27me3 demethylation, thereby favoring the expression of M2-related genes, whereas succinate accumulation can inhibit demethylase activity and sustain a pro-inflammatory transcriptional state ( It should be noted that most current evidence regarding amino acid-mediated regulation of macrophage polarization is derived from in vitro cell models or animal experiments, whereas systematic validation in human clinical samples remains relatively limited

Glutathione is a powerful antioxidant produced in our bodies from three amino acids: cysteine, glycine, and glutamic acid, with cysteine being the most critical for its creation

The red swollen mark (also known as wheals) can range from a few millimeters to the size of a hand or even larger

Available from: Accessed at Jan 30

It was named thanks to its observed effect of inducing delta-wave activity during measurement with an EEG

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