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Genghof DS (1970) Biosynthesis of ergothioneine and hercynine by fungi and actinomycetales
Flavonoids as promising natural compounds in the prevention and treatment of selected skin diseases
In mice fed Se deficient diets, testicular atrophy, reduced diameter of the seminiferous tubules, osseous metaplasia, and reduced spermatogenic activity were observed: no mitotic activity in spermatogonia, reduced the number of spermatogenic cell lines (including stem cells, pachytene spermatocytes, spermatids, and maturing sperms), and higher rates of abnormal morphology of sperm were found without difference in chromosomal abnormalities in spermatocytes (85, 100)
From there, the dose can continue increasing to 10 mg, 12.5 mg, and ultimately 15 mg if needed and tolerated
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