In between episodes of sickling, people with SCD are normally well
With neurological involvement, 1 mg intramuscularly on alternate days is given until no further improvement, then 1 mg every 2 months
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Before starting a vitamin B12 supplement, consult a doctor or nutritionist who can determine whether supplementation is needed and recommend the appropriate dose
If tiredness is due to low B12, treatment may help as levels improve
Tesofensine offers a central nervous system approach, suppressing appetite while simultaneously increasing resting energy expenditure through triple monoamine reuptake inhibition