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Mujaj said: "This was the first large study to investigate the relationship between aspirin use and incident heart failure in individuals with and without heart disease and at least one risk factor

Individual variation in response to GLP-1 receptor agonists is a primary consideration

Effects of DPP-4i on HF DPP-4 has been shown to directly increase factors that are predominant in HF

18 In a trial evaluating the impact of liraglutide on weight loss in T2D and obesity, an average weight loss of 6.4 kg was seen with liraglutide 3 mg daily and 5-kg loss with liraglutide 1.8 mg daily, versus 2.2 kg with placebo, at 56-week follow-up

This is particularly relevant in the aging brain, where insulin resistance and impaired glucose metabolism emerge years before overt cognitive symptoms

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