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Excessive ROS are prone to cause mitochondrial dysfunction, leading to impaired skin barrier development and abnormal skin defects ( FIGURE 5 4 Therapeutic strategies based on ROS regulation With the deepening understanding of the role of ROS in skin diseases, various therapeutic strategies targeting ROS regulation have been developed

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To determine the role of GpoA during pneumococcal infection, we constructed the gpoA mutant in the capsulated D39 strain (serotype 2), which is virulent in BALB/c mice using intranasal inoculation [38], and its corresponding revertant strain ( wt gpoA + )

Molecular docking predicts the initial binding sites and conformations of inhibitors at the enzymes active site

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