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An explanation of how we came to these new recommendations can be found in Vitamin B12: Rationale for Recommendations

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an unusual or allergic reaction to methylcobalamin, cobalt, other medicines, foods, dyes, or preservatives

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Under normal conditions, NNMT activity can consume substantial amounts of both nicotinamide and SAM, particularly in metabolically active tissues or during periods of metabolic stress

B12 serves as a cofactor for enzymes critical for DNA synthesis, red blood cell formation, and nervous system function