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Structural diversity among agonist-bound states has been directly visualized by cryo-EM of GLP-1R in complex with multiple peptide agonists, confirming that conformational plasticity at the extracellular face propagates to the G protein interface in agonist-specific ways (Cary et al., 2021)
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DSIP flux across the BMEC monolayers was also found to be bidirectional, insensitive to metabolic inhibitors, and not altered by high concentrations of tryptophan
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