Like cisplatin, it contains two chloride ligands, which are released within the cellular environment and interact with DNA to form intra- and interstrand cross-links.3 These DNA adducts trigger multiple cellular responses, including DNA damage recognition and repair, cell cycle arrest, and activation of apoptotic signaling pathways, ultimately inhibiting cell proliferation.4 Ovarian cancer remains one of the leading causes of mortality among gynecological malignancies, with epithelial ovarian carcinoma accounting for more than 90% of all cases.5 The current standard therapy involves primary cytoreductive surgery followed by platinum-based combination chemotherapy administered as soon as possible after surgery.6 However, a major limitation of these treatments is the dose-dependent toxicity associated with platinum compounds, which can result in significant off-target tissue injury.7 It is well established that Reactive Oxygen Species (ROS) generated during the metabolism of platinum-based agents contribute to this toxicity, particularly in the reproductive system
Making bloodwork work: the impact of sample collection, processing, and storage on plasma glutathione measurement, and implications for translation
The role of a cysteine and glutathione deficiency in the immunopathology of HIV infection
Declining estrogen and progesterone, combined with relative androgen dominance, can trigger diffuse thinning across the scalp
Inhibition of Haemophilus parasuis by berberine and proteomic studies of its mechanism of action
Rajguru ensures that every individual understands their treatment plan and feels confident about moving forward
