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The STEP UP trial, a Phase 3b study published in The Lancet Diabetes & Endocrinology in 2025, evaluated a 7.2 mg weekly injection dose in over 1,400 adults with obesity (BMI of 30 or higher) and without diabetes

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The Science Behind the Hormone GLP-1, short for Glucagon-Like Peptide-1, is a hormone produced in the intestines in response to food intake

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MC4R activation promotes increased energy expenditure through stimulation of sympathetic nervous system activity, brown adipose tissue thermogenesis, and enhanced fatty acid oxidation