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NICE guidance (NG238) does not currently recommend GLP-1 receptor agonists specifically for dyslipidaemia treatment, though their cardiovascular benefits are recognised in appropriate patient populations

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Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

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In July 2022, the FDAs Pharmacy Compounding Advisory Committee (PCAC) voted against inclusion of enclomiphene citrate on the final 503A bulks list, though the material remains listed as category 1 on the most recent iteration of the 503A bulk drugs list

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The cardiovascular safety of this dose of semaglutide is currently being evaluated in the SELECT trial, where 17,500 individuals with obesity and established CVD are randomised to semaglutide or placebo for 2.5-5 years

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