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Functional BAT in adults is detectable after exposure to mild cold (Saito et al., 2009) and its activity is inversely related to body mass index and body fat percentage (van Marken Lichtenbelt et al., 2009)
Where only incidence data were available, effect estimates were calculated using reported follow-up time and event counts
Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets
The beneficial effects of GLP-1 receptor activation on glycemia occur through several mechanisms: GLP-1 stimulates glucose-dependent insulin secretion from pancreatic -cells, suppresses inappropriately elevated glucagon secretion from pancreatic -cells, delays gastric emptying, and induces satiety via a direct action in the central nervous system
The FDA approved tirzepatide for weight loss in 2023
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