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The most bioavailable forms of B12 are methylcobalamin, hydroxocobalamin, and adenosylcobalamin

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However, taking periodic breaks (2-4 weeks off after each cycle) may help maintain effectiveness and prevent potential tolerance

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I didnt know how it would help, but was told that this is one of the things that your body has difficulty making, and because of digestion it was hard to get this in an effective form