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Sleep is equally relevant: testosterone is primarily produced during sleep, and research has found that even one week of sleeping five hours per night reduces testosterone levels by approximately 10 to 15% in young men, a reduction equivalent to ageing ten to fifteen years

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Alongside IL-1, MSU crystals also induce macrophages to produce caspase-11, a module that serves both as a recruiting agent for circulating neutrophils and a stimulatory cytokine prompting neutrophils to form NETs