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Figure 3 Clinical translation and human data taxonomy The translation of these mechanisms into human clinical data requires a strict evidence taxonomy to avoid conflating metabolic improvements with intrinsic disease modification
Treatment Duration and Expectations For optimal results, a minimum of 12 months on Tirzepatide or Semaglutide is recommended
Vitamin B12 deficiency can occur due to dietary restrictions (vegetarian or vegan diets), absorption issues (pernicious anemia or gut disorders like celiac disease or Crohns disease), age-related changes in elderly patients, or long-term use of certain medicines
Sasson says
The most effective way to treat a deficiency, other than reintegrating B12-rich foods into the diet, is through injection
