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Acknowledgements This work was supported by the US National Institutes of Health grant T32HL066987 (F.D.), a Scholar Fellowship from Coordenao de Aperfeioamento de Pessoal de Ensino Superior (CAPES) and the David Rockefeller Center for Latin American Studies at Harvard University (R.T.G.), a Science Without Borders Scholar Fellowship from Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) (R.B.P.) and the Brazilian National Institute of Science and Technology for Vaccines grant CNPq/Fapemig/MS 573547/2008-4 (R.T.G.)