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do Nascimento TS, Pereira ROL, et al
Lancet 405 , 15801593 (2025)
Rare but serious effects can include pancreatitis, gallbladder problems, kidney injury (often linked to dehydration from severe vomiting or diarrhea), severe or persistent abdominal pain, serious allergic reactions, worsening of diabetic retinopathy in people with type 2 diabetes, and low blood sugar especially if semaglutide is combined with insulin or sulfonylureas
or kidney problems - little or no urination
Alternatives like other prescription medications and lifestyle changes can also support weight management
Placebo assignment hits 20-25% of participants in most trials
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