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They offer more flexibility for larger volumes but the needles are typically thicker (25-27 gauge) and they require a separate needle attachment
3 The most directly relevant data for an insulin-resistance question come from the MASLD phase 2a trial (Sanyal et al., Nature Medicine , 2024)
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Chemogenetic activation of NTS GLP1 significantly suppressed appetite, mitigated obesity, and modulated hypothalamic pro-opiomelanocortin (POMC) and neuropeptide Y (NPY)
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Alongside its use for overweight and obesity, studies of the drug focused on treating non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH), a condition where fat builds up in the liver
