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IGF-1 LR3 contains a 13-amino-acid N-terminal extension and a glutamic acid substitution at position 3, reducing binding affinity for IGF-binding proteins (IGFBPs) by approximately 100-fold compared to endogenous IGF-1

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In the event of a serious adverse reaction that the patient and/or treating clinician believed to be caused by or related to the administration of semaglutide or metformin, the medication was discontinued, and the adverse event was reported to the investigator

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