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TMAO can change the bile acid spectrum to accelerate the formation of aortic lesions in ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis (82)

Synergy with Sleep: By injecting at night, the exogenous signal from Tesamorelin aligns with the body's natural "pulse" timing, potentially enhancing the amplitude of the nocturnal GH burst

Journal of Medical Internet Research

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