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Patients with genetic predispositions toward higher reward sensitivity may experience more pronounced cravings but also potentially greater benefit from semaglutide's reward-dampening effects

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The 3.5 kb 5-flanking region of Iba1 gene was PCR-amplified from mouse genomic DNA and inserted into pBstN-NCre vector 67 to generate Iba1-Cre plasmid

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Appetite reduction is often the first shift, followed by gradual, consistent weight loss when paired with healthy habits