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Diabetes Care 2007;30(4):813-6
This contraindication exists because MTC arises from the same C-cells that showed tumor formation in rodent studies, and individuals with MTC history may have underlying genetic susceptibility that could theoretically interact with GLP-1 receptor stimulation
Pecoits-Filho, A
Ketorolac*: Short-term pain relief (NSAID) that can be used for everything from migraines to acute pain, etc
Unsupervised telehealth prescribing of semaglutide without metabolic evaluation, without addressing the hormonal contributors to weight gain, and without structured dose titration produces variable results and misses the clinical opportunity
Before initiating Wegovy, healthcare professionals should establish a comprehensive baseline assessment including: Complete medical history and medication review Physical examination with baseline weight, BMI, and blood pressure Blood tests: HbA1c (if diabetic or at risk), lipid profile, liver function, kidney function, and thyroid function Assessment for contraindications (the UK SmPC lists hypersensitivity to semaglutide or any excipients as the only contraindication) Documentation of any existing neurological symptoms According to NICE TA875, Wegovy should be prescribed within specialist weight management services
