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Sadeghi A, Mousavi SM, Mokhtari T, Parohan M, Milajerdi A

The D-Phe inversion sits inside the conserved His-Phe-Arg-Trp message tetrapeptide that every melanocortin receptor recognises, and it is the substitution responsible for the markedly prolonged receptor occupancy reported for this analogue relative to alpha-MSH, because inverting that stereocentre removes a favoured chymotrypsin-like cleavage point

Clinical Trial Registration Number: NCT02306005 Supported by: The InLipoDiab1 study received funding from Diabetees Poland and Poznan University of Medical Sciences Disclosure: A

MHRA authorises Mounjaro (tirzepatide) for weight management and weight loss

These injectable medications contain a form of the hormone called GLP-1, which regulates insulin production in the body, suppresses hunger signals to the brain and slows digestion, a powerful weight-loss-promoting combination